This course will draw from multiple disciplines to provide a general understanding of molecular approaches to genotyping, as well as the understanding of genotype/phenotype relationships and gene-environment interactions as determinants of disease susceptibility. It will examine the molecular basis for interindividual differences in drug/xenobiotic disposition and application of that information for individualized drug treatment regimens and disease prevention strategies. It will also cover the application of array and sequencing technologies for the identification of disease susceptibility and drug response genes as well as potential environmental modifiers. Finally, it will explore ethics and policy issues relevant to testing for pharmacogenetic and toxicogenomic traits.
At the end of this course students should be able to:
- Explain the various technologies used to identify genetic polymorphisms, with particular emphasis on genes of pharmacological and environmental relevance.
- Be able to identify and understand the conceptual basis behind basic methodologies used to identify genetic variability in human DNA samples
- Explain the significance of genetic polymorphisms in the development, progression, and treatment of human disease.
- Appreciate the public health importance of genetic variability in specific multigene families of enzymes involved in metabolism of drugs and non-drug chemicals in the environment
- Understand the connection between environmental exposures, genetic polymorphisms, and risk for diseases of public health importance.
- Understand the role of genetic polymorphisms as determinants of adverse drug reactions and pharmacological efficacy.
- Read critically original scientific literature relating to ‘gene-environment interactions’
- Have the technical background necessary to appreciate the ethical, legal and social implications that arise out of pharmaco- and toxicogenomic research.
- Write professionally about one area of ‘gene-environment’ interaction with public health importance
- Integrate basic concepts of ethics into arguments for and against genotyping of populations for ‘environmental susceptibility’ genes.